This is an item I originally wrote for the Science on the Farm website. But because I briefly mentioned the A1/A2 milk thing in the last post, I thought I could usefully bring this across to the Bioblog as well.
The 2006 Scholarship Biology paper included a question on the genetics of A1 and A2 milk. It’s worth revisiting this here, because it’s a good example of patterns of inheritance and the way an allele may spread through a population. (We are not going to discuss the possible public-health implications of the two alleles.)
In a Friesan-based dairy herd, around 30% of cows will be homozygous for the A2 allele, with 30% homozygous for A1 and 40% heterozygous. The proportion of A2 homozygotes is higher in Jersey herds – but there is also a lot of variation between herds (Woodward, 2004).
If the A2 allele was, as scientists believe, the original form of the beta casein gene, how did the A1 allele arise and what explains its present distribution in the NZ dairy herd?
Since the A1 & A2 forms of beta casein differ by only a single amino acid, the A1 allele must have originated as a point mutation in the beta casein gene. And this mutation must have occurred in the germ-line cells that produce gametes. or during gamete production itself, otherwise the A1 allele could not have entered the gene pool.
How would natural selection act on indivduals carriying this new allele? Because casein is expressed in the milk, then selection would work on the individual’s offspring. If the A1 variant had an adverse effect on calves drinking it, those calves would be less likely to survive and reproduce – so their parent’s genes would not be passed on. If it benefited the calves’ health in some way, then the allele would be selected for (through enhanced survival and reproduction of the calves. A third possibility is that the mutation is neutral, in which case its frequency in the population could be affected by genetic drift, or through its being linked to another, beneficial gene. Farming practices (artificial selection) may also affect the allele’s frequency. For example, mating is non-random, with much of the dairy herd inseminated artifically using semen from a relatively small number of bulls. If some of these bulls carried the A1 allele, its frequency in the population’s gene pool could increase relatively quickly. So both natural and artifical selection may have led to evolution: a change in allele frequency in the gene pool of our dairy herds.